Albumin-adjusted calcium equation and reference interval for adjusted calcium. Data from the UK Biobank

Derivation and internal validation of an equation for albumin-adjusted calcium

BACKGROUND Previously published equations to adjust calcium for albumin concentration may vary depending on factors such as the type of reagents used. Albumin-adjusted calcium equations derived from laboratories using the bromocresol purple (BCP) albumin binding reagent have not been described. METHODS The linear regression equation for the binding of calcium and BCP-albumin was derived in a ...

pH-adjusted ionized calcium

Albumin-adjusted calcium concentration in serum increases during normal pregnancy.

Concentrations of total calcium and albumin were measured in serum specimens from 41 women at intervals before, during, and after 42 pregnancies. The albumin concentration decreased but the calcium decreased more slowly, so that the albumin-adjusted calcium concentration increased from conception to term. These findings, taken in conjunction with published observations of hypercalciuria, increa...

Author's response to reviews Title: Derivation and internal validation of an equation for albumin-adjusted calcium Authors:

Adjusted Interval Digraphs

Interval digraphs were introduced by West et all. They can be recognized in polynomial time and admit a characterization in terms of incidence matrices. Nevertheless, we do not have a forbidden structure characterization nor a low-degree polynomial time algorithm. We introduce a new class of ‘adjusted interval digraphs’, obtained by a slight change in the definition. By contrast, these digraphs...